Angry Birds, the most popular game for smartphones, has a Web interface. You can install it as a Chrome app or play it from chrome.angrybirds.com using the latest versions of the most important browsers.
Nelson Minar says that "calling it Chrome Angry Birds is missing the point because what's really interesting is that it's a real-time multimedia cross-platform HTML 5 app" and he's right. Angry Birds works well in Internet Explorer 9 and even in Firefox 3.6, but there are some upcoming features that will only work if you install the Chrome app: for example, in-app payments.
The game caches most of the resources, so you can play it offline.