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September 18, 2008

Sergey Brin Launches Personal Blog


The most outgoing Google co-founder, Sergey Brin, launched a personal blog at too.blogspot.com. "While Google is a play on googol, too is a play on the much smaller number - two. It also means in addition, as this blog reflects my life outside of work," explains Sergey Brin.

The first blog post is somber: Sergey discovered that he has a "higher chance of developing Parkinson's in [his] lifetime than the average person".
My mother had always been haunted by Parkinson's because her aunt had suffered from it. I had often reasoned with her that since Parkinson's is not hereditary (there is not a strong correlation of Parkinson's incidence among close relatives), she had little to fear.

In 2004, my wife, Anne, introduced me to her future cofounders in 23andMe as they were studying the genetics of Parkinson's Disease. As with my mother's fear, I was skeptical about the study. I reasoned that if there was much to be learned about Parkinson's in the genome, there would have to be a high percentage of inherited cases. In fact, I appeared to be right in that this particular study did not bear immediate fruit. (...)

So, when my wife asked me to look up G2019S in my raw data (23andMe scientists had had the forethought to include it on their chip), I viewed it mostly as entertainment. But, of course, I learned something very important to me -- I carry the G2019S mutation and when my mother checked her account, she saw she carries it too.

The exact implications of this are not entirely clear. Early studies tend to have small samples with various selection biases. Nonetheless it is clear that I have a markedly higher chance of developing Parkinson's in my lifetime than the average person. In fact, it is somewhere between 20% to 80% depending on the study and how you measure.

{ via Bradley Horowitz }

13 comments:

  1. I too have a blog. But he deserves that we remember its life and done. (translation by google)

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  2. Sergeys blog shows that 23andME incentive to 'democratize personal gentics' can be a mixed blessing for those having their DNA screened.

    Is Sergey better off knowing he has a large chance at getting Parkinson's? Because knowing there is a chance can be a burden in itself. Would you feel better off knowing you have a chance at a number of genetically determinable diseases - which not all may be treatable? Doesn't the saying apply: 'ignorance is bliss'?

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  3. See also: https://www.23andme.com/more/considerations/

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  4. There is a lot of research on Parkinson's disease, some fairly encouraging. One advantage to Sergey's knowing is that he is in a position to fund such research. Maybe the Google $$$ will benefit him in ways he never expected. Good luck to him.

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  5. Good on him. My grandfather had this disease, so any awareness that can help progress is a good thing.

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  6. There is a lot of research on Parkinson's disease, some fairly encouraging. One advantage to Sergey's knowing is that he is in a position to fund such research. Maybe the Google $$$ will benefit him in ways he never expected. Good luck to him.

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  7. yes Good luck to him.
    knowing is that he is in a position to fund such research

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  8. Nice article. İm looking now. Thanx man ;)

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  9. Unfortunately, Sergey Brin's blog does not have an option to reply or write him a message. I've could tell him how to live longer and avoid the disease he has, or perhaps give an advice, or someone else could, but he might think that he knows everything by himself already and does not need more info on this subject. So, what's the purpose to spread a word about your health without having a friendly conversation? Anyway, check how АСД-2 can help you.

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  10. My grandfather had this disease, so any awareness that can help progress is a good thing.very good

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  11. How much should you worry about this though? I guess it depends on your age. Who knows, by the time you reach the age where Parkinsons becomes a real issue, they might already have a cure! Fingers crossed.

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  12. I am trying to get in touch with Mr. Brin regarding a promising therapy for SCI, and neurological conditions such as Parkinson's disease. Can anyone suggest anything? This is my letter to Mr. Brin:

    Dear Mr. Brin,

    I have read numerous articles about your being a carrier for gene LRRK2 which potentially puts you at a theoretically higher risk of developing Parkinson's disease. Given this situation, you determined to put your communication and financial means to good use in an attempt to find a cure for a disease you may actually never get. This approach, which is both preventive and active, denotes your lucidity and refusal to become a victim of a neurological degenerative affliction.

    I am writing today to give you the opportunity to become involved in developing a combined therapy to treat Parkinson's disease, without precluding other research routes, and also take part in the development of a therapy to treat numerous other afflictions of the spinal cord, including paraplegia and quadriplegia.

    I am a member of Neurogel en Marche Association, an association of paralyzed people who, just like you, have decided to take charge of their future and have managed to secure the patent for a therapeutic tool called Neurogel. Neurogel is a bioadhesive three-dimensional hydrogel, which is biocompatible with the brain.

    Our Association has a scientific council made up of international noted scientists and is prepared to conduct clinical trials on humans within a short time, through different approaches and techniques. Professor Alfredo Gorio, from the University of Milan, member of our scientific council, would like to conduct a study in which Neurogel would be implanted in the brain, at the level of the necrosis. As a result of the gel's tissular intergration, he could use this drug reservoir for all the molecules currently acitve and whatever the stage of Parkinson's disease. Pr. Gorio's work goes even further. He has isolated a certain type of stem cells from the amniotic liquid, and was able to modify these cells and clone them into nerve stem cells which have extremely high resistance and life capacities, even in poorly vascularized environments.

    Although Pr. Gorio is also working on other studies to use Neurogel and his new line of stem cells within the framework of lesions of the spinal cord, he is prepared to meet with you to present and explain the pre-clinical he would like to conduct.

    I hope to have the honor of putting you in touch with Professor Gorio as soon as possible and to give you the opportunity to be part of a global venture to treat invalidating affections of the CNS.

    Sincerely,

    Michele Zander
    Member, point of contact for Neurogel en Marche
    www.neurogelenmarche.org

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